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Eloxatin - News Articles

Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria


Results: This study showed dose-dependent cytotoxic effects of cisplatin, oxaliplatin and doxycycline in HT29 colorectal cancer cells. Doxycycline showed inhibition of cytochrome-c-oxidase activity in these cells over a time-period. The pre-treatment of doxycycline reported statistically significant ...
Detecting acute neurotoxicity during platinum chemotherapy by neurophysiological assessment of motor nerve hyperexcitability


Platinum-based drugs, such as cisplatin and oxaliplatin, are well-known for inducing chronic sensory neuropathies but their acute and motor neurotoxicities are less well characterised. Use was made of nerve conduction studies and needle electromyography (EMG) to assess motor nerve ...
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But only 14% of the oldest group received an oxaliplatin-containing regimen, compared with 44% in the younger group. Early adverse effects were somewhat ...
Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue


Oxaliplatin treatment did not alter the size profile of ATP7A-immunoreactive neurons but significantly reduced the size profile of CTR1-immunoreactive neurons. ATP7B mRNA was barely detectable, and no specific immunoreactivity for ATP7B was found, in DRG tissue from healthy ...
Anti-tumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro


The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxaliplatin (L-OHP) in human oxaliplatin-resistant gastric cancer cells. Methods: After producing oxaliplatin-resistant gastric cancer cells, cell morphology, growth and doubling time were observed, ...
Briefing.com:


but Sanofi-Aventis (SNY) has been a bit of a drag after it settled with additional drugmakers a patent lawsuit over cancer drug Eloxatin. In Asia, the MSCI Asia Pacific Index advanced 0.4%, while Japan’s Nikkei slipped 0.5%. Shares of Japanese exporters retreated ...
Sanofi settles further Eloxatin patent suits | Business News | Reuters


PARIS (Reuters) - Sanofi-Aventis has settled a patent law suit over cancer drug Eloxatin with additional drugmakers, stopping them selling their generic versions in the United States from June 30 until August 2012. ...
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